Effect of arsenic trioxide on QT interval in patients with advanced malignancies.

@article{Barbey2003EffectOA,
  title={Effect of arsenic trioxide on QT interval in patients with advanced malignancies.},
  author={Jean T. Barbey and John Christopher Pezzullo and Steven L. Soignet},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2003},
  volume={21 19},
  pages={3609-15}
}
PURPOSE Arsenic trioxide is an effective treatment for patients with acute promyelocytic leukemia (APL) who have relapsed from or are refractory to all-trans-retinoic acid and anthracycline chemotherapy. Since arsenic can prolong the QT interval and lead to torsade de pointes, a life-threatening ventricular arrhythmia, this retrospective analysis was conducted to determine the degree of QT prolongation in patients treated with arsenic trioxide. PATIENTS AND METHODS Clinical data and serial… CONTINUE READING

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