Effect of arsenic and cadmium on the persistence of mutagen-induced DNA lesions in human cells.

@article{Hartmann1996EffectOA,
  title={Effect of arsenic and cadmium on the persistence of mutagen-induced DNA lesions in human cells.},
  author={Andreas Hartmann and Guenter Speit},
  journal={Environmental and molecular mutagenesis},
  year={1996},
  volume={27 2},
  pages={98-104}
}
The alkaline single cell gel electrophoresis (SCG test or comet assay) was used to characterize the influence of sodium arsenite (NaAsO2) and cadmium sulphate (CdSO4) on the persistence of mutagen-induced DNA lesions. Human blood and SV4O-transformed fibroblasts (MRC5CV1) were treated for 2 hr with methyl methanesulphonate (MMS) or benzo(a)pyrene (BaP). MMS induced concentration-related DNA damage in white Blood cells (WBC) and fibroblasts in similar concentrations. For the induction of DNA… CONTINUE READING
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