Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model.

@article{Yue1995EffectOA,
  title={Effect of aromatase inhibitors on growth of mammary tumors in a nude mouse model.},
  author={Wei Ping Yue and J Wang and Alexei Y Savinov and A. Brodie},
  journal={Cancer research},
  year={1995},
  volume={55 14},
  pages={3073-7}
}
The effects of aromatase inhibitors 4-hydroxyandrostenedione (4-OHA), CGS 16949A, and CGS 20267, and of the antiestrogen tamoxifen (TAM), were studied on the growth of human breast carcinoma in a nude mouse model. To simulate the postmenopausal breast cancer patient, tumors were formed from inoculates of MCF-7 cells transfected with the human aromatase gene to provide a source of non-ovarian estrogen in ovariectomized mice. Tumor growth was significantly inhibited by all treatments (P < 0.05… CONTINUE READING
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