Effect of aripiprazole on 5-HT2 receptor-mediated wet-dog shake responses and disruption of prepulse inhibition in rats.

@article{Kohnomi2008EffectOA,
  title={Effect of aripiprazole on 5-HT2 receptor-mediated wet-dog shake responses and disruption of prepulse inhibition in rats.},
  author={Shuntaro Kohnomi and Katsuya Suemaru and Hiromu Kawasaki and Hiroaki Araki},
  journal={Journal of pharmacological sciences},
  year={2008},
  volume={106 4},
  pages={
          645-50
        }
}
Aripiprazole, an atypical antipsychotic drug, is a D(2) dopamine-receptor partial agonist, but also has affinity to several serotonin receptors (5-HT(1A,2A,2C,7)). However, little is known about the contribution of serotonin receptors in the action of aripiprazole. The present study investigated the effects of aripiprazole on 5-HT(2A) receptor-mediated behaviors and compared them with the effects on dopamine receptor-mediated behavior in rats. Aripiprazole (10, 30 mg/kg, p.o.) inhibited the… CONTINUE READING

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