Effect of arachidonic acid metabolites on bone resorption by isolated rat osteoclasts.

@article{Fuller1989EffectOA,
  title={Effect of arachidonic acid metabolites on bone resorption by isolated rat osteoclasts.},
  author={Karen Fuller and Timothy John Chambers},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1989},
  volume={4 2},
  pages={209-15}
}
Arachidonic acid metabolites (eicosanoids) have major effects on bone but their role is unclear. Many are known to stimulate bone resorption in organ culture, but paradoxically, previous work has suggested that at least some of them act as direct inhibitors of osteoclastic function. In an attempt to clarify the role of eicosanoids in bone physiology, we have defined the duration of action and relative potencies of prostaglandin (PG) E1 and E2 and have extended the range of eicosanoids tested on… CONTINUE READING
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