Effect of antisense RNA targeting Polo-like kinase 1 on cell growth in A549 lung cancer cells

Abstract

In order to investigate the effect of Polo-like kinase-1 (Plk1) depletion on cell cycle progression and cell growth in lung cancer cells, a recombinant plasmid containing antisense RNA targeting Plk1 (pcDNA3-Plk1) was transfected into A549 cells by lipofectine. RT-PCR and Western-blot were used to detect the Plk1 gene expression. Cell proliferation was… (More)
DOI: 10.1007/s11596-008-0106-9

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