Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice

  title={Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice},
  author={S. Brody and F. Conquet and M. Geyer},
  • S. Brody, F. Conquet, M. Geyer
  • Published 2003
  • Medicine
  • Psychopharmacology
  • RationalePrepulse inhibition of the startle response (PPI), a model of sensorimotor gating, is deficient in persons with schizophrenia. In rodents, the reversal of induced deficits in PPI demonstrates predictive validity for identifying antipsychotic treatments. Metabotropic glutamate receptor 5 (mGluR5) has been implicated in schizophrenia, in part because mGluR5 knockout (KO) mice exhibit PPI deficits.ObjectiveWe examined whether mGluR5 KO mice might serve as a novel model for detecting… CONTINUE READING
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