Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin.

@article{Gallager1976EffectOA,
  title={Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin.},
  author={Dorothy W. Gallager and George K. Aghajanian},
  journal={European journal of pharmacology},
  year={1976},
  volume={39 2},
  pages={357-64}
}
As reported in the preceding study, the ability of certain antipsychotic and adrenolytic agents to inhibit the spontaneous firing of serotonergic 5HT neurons in the dorsal raphe nucleus appeared to be related to adrenergic blocking efficacy. However, the interaction between adrenergic and serotonergic systems was apparently indirect. In this phase of the study we investigated the hypothesis that another transmitter system could mediate this interaction. We examined the effects of two inhibitory… CONTINUE READING

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