Effect of antioxidant therapy on blood pressure and NO synthase expression in hypertensive rats.

@article{Vaziri2000EffectOA,
  title={Effect of antioxidant therapy on blood pressure and NO synthase expression in hypertensive rats.},
  author={Nosratola D. Vaziri and Zhenmin Ni and Fariba Oveisi and D L Trnavsky-Hobbs},
  journal={Hypertension},
  year={2000},
  volume={36 6},
  pages={957-64}
}
Earlier studies have demonstrated evidence for increased reactive oxygen species, enhanced NO synthase (NOS) expression, and elevated NO production in spontaneously hypertensive rats (SHR). Given the negative-feedback regulation of NOS by NO, we hypothesized that enhanced NO inactivation by ROS may contribute to compensatory upregulation of NOS in SHR. The present study was designed to test this hypothesis. Eight-week-old male SHR and Wistar-Kyoto rats were treated for 3 weeks with either a… CONTINUE READING