Effect of antineoplastic and cytotoxic Mannich Bases derived from conjugated styryl ketones on mitochondrial respiration in rat liver cells.

Abstract

Five cytotoxic Mannich bases (5-dimethylamino-1-substituted phenyl-1-penten-3-ones), three having antineoplastic activity, were evaluated for respiratory-inhibiting properties in rat liver mitochondria in the presence of four substrates: succinate, glutamate, 3-hydroxybutyrate, and palmitylcarnitine. Four compounds (Ib--Ie) showed significant inhibiting… (More)

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@article{Hamon1978EffectOA, title={Effect of antineoplastic and cytotoxic Mannich Bases derived from conjugated styryl ketones on mitochondrial respiration in rat liver cells.}, author={Nad{\`e}ge Hamon and D L Bassendowski and Debbie E. Wright and Jonathan R. Dimmock and Luke M Noble}, journal={Journal of pharmaceutical sciences}, year={1978}, volume={67 11}, pages={1539-42} }