• Corpus ID: 5564442

Effect of antimalarial drugs on human neutrophil chemotaxis in vitro.

@article{Kharazmi1983EffectOA,
  title={Effect of antimalarial drugs on human neutrophil chemotaxis in vitro.},
  author={Arsalan Kharazmi and Niels Henrik Valerius and Niels H{\o}iby},
  journal={Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology},
  year={1983},
  volume={91 4},
  pages={
          293-8
        }
}
  • A. KharazmiN. ValeriusN. Høiby
  • Published 1 August 1983
  • Medicine, Biology
  • Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology
The effect of several antimalarial drugs, commonly used for prophylaxis and therapy of human malaria, on polymorphonuclear leukocyte chemotaxis was studied. A modified, reversible Boyden chamber method was used. Various concentrations of each drug was mixed with neutrophils and incubated in the chambers for 2 1/2 hours. After the incubation period percent inhibition of chemotaxis was determined. It was shown that chloroquine, quinine, proguanil, and tetracycline at concentrations frequently… 

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