Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study

  title={Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study},
  author={H. Lee and In-Kyu Chang and Y. H. Lee and C Kim and Y J Seo and J. S. H. Lee and Myung Im},
  journal={Journal of the European Academy of Dermatology and Venereology},
  • H. LeeI. Chang M. Im
  • Published 1 December 2014
  • Medicine
  • Journal of the European Academy of Dermatology and Venereology
BACKGROUND Isotretinoin has been frequently used for acne therapy. [] Key Method Twenty patients were treated with isotretinoin and 20 patients were treated with additional antihistamine, desloratadine. Assessment was made at baseline, after 2, 4, 8 and 12 weeks of treatment.

Preliminary evaluation of the clinical efficacy of antihistamines as an adjuvant treatment to isotretinoin for acne vulgaris

Acne patients may experience better efficacy and clinical cure from the adjuvant use of H1-antagonists in combination with systemic isotrertinoin, although the occurrence of cutaneous side effects of isotretinoin is not affected by such combination.

Efficacy of Isotretinoin and Antihistamine versus Isotretinoin Alone in the Treatment of Moderate to Severe Acne : A Randomised Control

Use of antihistamine with isotretinoin provides synergic effect while minimizing the side effect of isot retinoin and greater clearance of the lesion and scars.

Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Common Vulgaris Acne in Vietnamese Patients

In the treatment of moderate acne vulgaris, oral isotretinoin in combination with desloratadine is more effective and has fewer side effects than using isot retinoin alone.

Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris.

Antihistamine: A Useful Medication with Minimal Adverse Drug Reactions to Improve Acne Symptoms and Reduce Sebum Production

Both studies demonstrate the usefulness of an histamine antagonist in reducing sebum production and improving acne symptoms, and a recommendation can be made for antihistamine to treat acne vulgaris as an adjuvant therapy to standardized treatment.

The clinical efficacy of desloratadine, a non-sedating antihistamine, in the management of allergic conditions: A review of the evidence

Current evidence suggest that desloratadine is an ideal option for most of the allergic conditions due to its efficacy as well as favourable safety and tolerability profile.

Use of H-1 Antihistamine in Dermatology: More than Itch and Urticaria Control: A Systematic Review

Benefits were observed when H-1 antihistamines were used either alone or in combination with other therapeutic modalities, and the evidence level of most included studies is weak.

Nutritional factors associated with acne vulgaris

It is hypothesized that milk consumption affects the presence of both reproductive, nonreproductive hormones, and growth factors in the authors' body, which may contribute to increased acne prevalence, and a randomized controlled trial to determine the cause and effects nature of this relationship.

A consensus‐based practical and daily guide for the treatment of acne patients

Many current guidelines provide detailed evidence‐based recommendations for acne treatment, and these recommendations are often based on clinical practice, animal studies, and peer-reviewed literature.

Managing acne in the Middle East: consensus recommendations

Information about the management of acne in the Middle East is somewhat sparse; however, several studies have recently been conducted and will be discussed in this supplement.



Effectiveness of conventional, low‐dose and intermittent oral isotretinoin in the treatment of acne: a randomized, controlled comparative study

This study presents data regarding the efficacy of low‐dose and intermittent isotretinoin treatment in patients with acne, and compares these three therapeutic regimens simultaneously.

High‐dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life

This data indicates that even at recommended doses of 0.5‐1.0 mg/kg/day for 5‐6 months, isotretinoin is associated with high rates of permanent remission, however, more than 20% of patients experience a relapse within two years that requires further medical management.

Uses and complications of isotretinoin therapy.

Isotretinoin (13-cis-retinoic acid) is a retinoid used over the past 2 decades to treat a wide variety of dermatologic conditions, some with great success, and the clinical applications of oral retinoids continue to expand both within and beyond the field of dermatology.

Itching in acne--an unusual complication of therapy.

Pruritus at the site of active acne has not been described before as a complication of acne therapy, and increased awareness of this uncommon complication helps prevent the unnecessary discontinuation of effective acne therapy.

Comparison of the epidemiology of acne vulgaris among Caucasian, Asian, Continental Indian and African American women

There are few large objective studies comparing acne epidemiology between racial and ethnic groups and this work is one of the first studies of its kind.

Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine

Background Desloratadine is a non‐sedating, clinically effective, anti‐allergic therapy that has been shown to exhibit anti‐inflammatory properties that extend beyond its ability to antagonize

Desloratadine: A new, nonsedating, oral antihistamine.

  • R. GehaE. Meltzer
  • Medicine, Biology
    The Journal of allergy and clinical immunology
  • 2001
Clinical experience in over 2300 patients has shown that the adverse event profile of desloratadine is similar to that of placebo; deslor atadine has no clinically relevant effects on electrocardiographic parameters, does not impair wakefulness or Psychomotor performance, and does not exacerbate the psychomotor impairment associated with alcohol use.

New developments in our understanding of acne pathogenesis and treatment

A summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years is provided.

Epidemiology of acne vulgaris

A systematic review of relevant epidemiological studies found no clear evidence of dietary components increasing acne risk and one small randomized controlled trial showed that low glycaemic index (GI) diets can lower acne severity.