Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study

@article{Lee2014EffectOA,
  title={Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study},
  author={H. Lee and In-Kyu Chang and Y. H. Lee and C D Kim and Y J Seo and Ji Hae Lee and Myung Im},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2014},
  volume={28}
}
  • H. Lee, I. Chang, +4 authors M. Im
  • Published 1 December 2014
  • Medicine
  • Journal of the European Academy of Dermatology and Venereology
BACKGROUND Isotretinoin has been frequently used for acne therapy. [...] Key Method Twenty patients were treated with isotretinoin and 20 patients were treated with additional antihistamine, desloratadine. Assessment was made at baseline, after 2, 4, 8 and 12 weeks of treatment. Expand
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Both studies demonstrate the usefulness of an histamine antagonist in reducing sebum production and improving acne symptoms, and a recommendation can be made for antihistamine to treat acne vulgaris as an adjuvant therapy to standardized treatment.
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