Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study

@article{Lee2014EffectOA,
  title={Effect of antihistamine as an adjuvant treatment of isotretinoin in acne: a randomized, controlled comparative study},
  author={H. Lee and In-Kyu Chang and Y. H. Lee and C D Kim and Y J Seo and Ji Hae Lee and Myung Im},
  journal={Journal of the European Academy of Dermatology and Venereology},
  year={2014},
  volume={28}
}
  • H. Lee, I. Chang, +4 authors M. Im
  • Published 1 December 2014
  • Medicine
  • Journal of the European Academy of Dermatology and Venereology
BACKGROUND Isotretinoin has been frequently used for acne therapy. [...] Key Method Twenty patients were treated with isotretinoin and 20 patients were treated with additional antihistamine, desloratadine. Assessment was made at baseline, after 2, 4, 8 and 12 weeks of treatment. Expand
Preliminary evaluation of the clinical efficacy of antihistamines as an adjuvant treatment to isotretinoin for acne vulgaris
TLDR
Acne patients may experience better efficacy and clinical cure from the adjuvant use of H1-antagonists in combination with systemic isotrertinoin, although the occurrence of cutaneous side effects of isotretinoin is not affected by such combination.
Efficacy of Isotretinoin and Antihistamine versus Isotretinoin Alone in the Treatment of Moderate to Severe Acne : A Randomised Control
Pandey D, Agrawal S. Efficacy of Isotretinoin and Antihistamine versus Isotretinoin Alone in the Treatment of Moderate to Severe Acne: A Randomised Control Trial. Kathmandu Univ Med J.
Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Common Vulgaris Acne in Vietnamese Patients
TLDR
In the treatment of moderate acne vulgaris, oral isotretinoin in combination with desloratadine is more effective and has fewer side effects than using isot retinoin alone.
Top Ten List of Clinical Pearls in the Treatment of Acne Vulgaris.
TLDR
Tips include how to optimize available treatment regimens according to the evidence base and target therapy to pathophysiologic factors, while also tailoring treatments to patient expectation and needs.
Antihistamine: A Useful Medication with Minimal Adverse Drug Reactions to Improve Acne Symptoms and Reduce Sebum Production
TLDR
Both studies demonstrate the usefulness of an histamine antagonist in reducing sebum production and improving acne symptoms, and a recommendation can be made for antihistamine to treat acne vulgaris as an adjuvant therapy to standardized treatment.
The clinical efficacy of desloratadine, a non-sedating antihistamine, in the management of allergic conditions: A review of the evidence
TLDR
Current evidence suggest that desloratadine is an ideal option for most of the allergic conditions due to its efficacy as well as favourable safety and tolerability profile.
Use of H-1 Antihistamine in Dermatology: More than Itch and Urticaria Control: A Systematic Review
TLDR
Benefits were observed when H-1 antihistamines were used either alone or in combination with other therapeutic modalities, and the evidence level of most included studies is weak.
Nutritional factors associated with acne vulgaris
TLDR
It is hypothesized that milk consumption affects the presence of both reproductive, nonreproductive hormones, and growth factors in the authors' body, which may contribute to increased acne prevalence, and a randomized controlled trial to determine the cause and effects nature of this relationship.
A consensus‐based practical and daily guide for the treatment of acne patients
TLDR
Many current guidelines provide detailed evidence‐based recommendations for acne treatment, and these recommendations are often based on clinical practice, animal studies, and peer-reviewed literature.
Managing acne in the Middle East: consensus recommendations
TLDR
Information about the management of acne in the Middle East is somewhat sparse; however, several studies have recently been conducted and will be discussed in this supplement.
...
1
2
...

References

SHOWING 1-10 OF 29 REFERENCES
Effectiveness of conventional, low‐dose and intermittent oral isotretinoin in the treatment of acne: a randomized, controlled comparative study
TLDR
This study presents data regarding the efficacy of low‐dose and intermittent isotretinoin treatment in patients with acne, and compares these three therapeutic regimens simultaneously.
High‐dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life
TLDR
This data indicates that even at recommended doses of 0.5‐1.0 mg/kg/day for 5‐6 months, isotretinoin is associated with high rates of permanent remission, however, more than 20% of patients experience a relapse within two years that requires further medical management.
Uses and complications of isotretinoin therapy.
TLDR
Isotretinoin (13-cis-retinoic acid) is a retinoid used over the past 2 decades to treat a wide variety of dermatologic conditions, some with great success, and the clinical applications of oral retinoids continue to expand both within and beyond the field of dermatology.
Itching in acne--an unusual complication of therapy.
TLDR
Pruritus at the site of active acne has not been described before as a complication of acne therapy, and increased awareness of this uncommon complication helps prevent the unnecessary discontinuation of effective acne therapy.
Comparison of the epidemiology of acne vulgaris among Caucasian, Asian, Continental Indian and African American women
TLDR
There are few large objective studies comparing acne epidemiology between racial and ethnic groups and this work is one of the first studies of its kind.
Inhibition of cytokine generation and mediator release by human basophils treated with desloratadine
Background Desloratadine is a non‐sedating, clinically effective, anti‐allergic therapy that has been shown to exhibit anti‐inflammatory properties that extend beyond its ability to antagonize
Acne vulgaris: pathogenesis, treatment, and needs assessment.
TLDR
The epidemiology, pathogenesis, and treatment of acne vulgaris are discussed and the burden of disease in the United States and future directions in the management of acne are addressed.
Desloratadine: A new, nonsedating, oral antihistamine.
TLDR
Clinical experience in over 2300 patients has shown that the adverse event profile of desloratadine is similar to that of placebo; deslor atadine has no clinically relevant effects on electrocardiographic parameters, does not impair wakefulness or Psychomotor performance, and does not exacerbate the psychomotor impairment associated with alcohol use.
New developments in our understanding of acne pathogenesis and treatment
TLDR
A summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years is provided.
Epidemiology of acne vulgaris
TLDR
A systematic review of relevant epidemiological studies found no clear evidence of dietary components increasing acne risk and one small randomized controlled trial showed that low glycaemic index (GI) diets can lower acne severity.
...
1
2
3
...