Effect of antigen-processing efficiency on in vivo T cell response magnitudes.

@article{Vijh1998EffectOA,
  title={Effect of antigen-processing efficiency on in vivo T cell response magnitudes.},
  author={Sujata Vijh and Ingrid M. Pilip and Eric G. Pamer},
  journal={Journal of immunology},
  year={1998},
  volume={160 8},
  pages={3971-7}
}
T lymphocytes eradicate and provide long-term immunity to infections caused by intracellular pathogens. The mechanisms that determine in vivo T cell response sizes are poorly understood. Although it is speculated that the relative processing efficiency of different epitopes determines the hierarchy of T cell responses following immunization, this hypothesis has not been rigorously tested. We therefore mutagenized the secreted p60 Ag of Listeria monocytogenes to alter the efficiency of T cell… CONTINUE READING

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