Effect of anticoagulants on the protein corona-induced reduced drug carrier adhesion efficiency in human blood flow.

@article{Sobczynski2017EffectOA,
  title={Effect of anticoagulants on the protein corona-induced reduced drug carrier adhesion efficiency in human blood flow.},
  author={Daniel J. Sobczynski and Omolola Eniola-Adefeso},
  journal={Acta biomaterialia},
  year={2017},
  volume={48},
  pages={186-194}
}
Plasma proteins rapidly coat the surfaces of particulate drug carriers to form a protein corona upon their injection into the bloodstream. The high presence of immunoglobulins in the corona formed on poly(lactic-co-glycolic acid) (PLGA) vascular-targeted carrier (VTC) surfaces was recently shown to negatively impact their adhesion to activated endothelial cells (aECs) in vitro. Here, we characterized the influence of anticoagulants, or their absence, on the binding efficiency of VTCs of various… CONTINUE READING
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