Effect of anticholinergics on positive and negative symptoms in schizophrenia.

  title={Effect of anticholinergics on positive and negative symptoms in schizophrenia.},
  author={Rajiv Tandon and John R Dequardo and J A Goodson and Niti Mann and John F. Greden},
  journal={Psychopharmacology bulletin},
  volume={28 3},
Anticholinergic drugs have been assumed to have no effects on schizophrenic symptomatology. Some studies suggest, however, that anticholinergic agents may antagonize the beneficial effect of neuroleptics on positive symptoms and partially ameliorate negative symptoms. Virtually all studies have been conducted in patients receiving concomitant neuroleptic treatment, raising the possibility that neuroleptics may obscure or modify any "true" anticholinergic effect on schizophrenic symptoms. To… CONTINUE READING

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