Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.

@article{Giri1993EffectOA,
  title={Effect of antibody to transforming growth factor beta on bleomycin induced accumulation of lung collagen in mice.},
  author={Shri N. Giri and Dallas M. Hyde and Mannfred A. Hollinger},
  journal={Thorax},
  year={1993},
  volume={48 10},
  pages={959-66}
}
BACKGROUND Increased production of transforming growth factor beta (TGF-beta) seems to have an important role in the pathophysiology of bleomycin induced lung fibrosis. This is attributed to the ability of TGF-beta to stimulate infiltration of inflammatory cells and promote synthesis of connective tissue, leading to collagen deposition. METHODS The study was designed to evaluate the antifibrotic potential of TGF-beta antibody in mice treated with bleomycin, which is a model of lung fibrosis… CONTINUE READING