Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats

@article{Fukumoto2004EffectOA,
  title={Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats},
  author={Koji Fukumoto and Isao Nagaoka and Atsuyuki Yamataka and Hiroyuki Kobayashi and Toshihiro Yanai and Yoshifumi Kato and Takeshi Miyano},
  journal={Pediatric Surgery International},
  year={2004},
  volume={21},
  pages={20-24}
}
Cathelicidins are a family of antibacterial peptides. Human cathelicidin LL-37 inhibits the binding of endotoxin lipopolysaccharide (LPS) to CD14-positive cells and could ameliorate sepsis. The aim of this study was to observe the effect of LL-37 on sepsis in neonatal rats. Intraperitoneal injection (IPI) of LPS was used to create sepsis in suckling rats. Group 1 rats were given LPS with LL-37, group 2 rats were given LL-37 2 h after LPS, and group 3 rats were given LPS without LL-37. Control… CONTINUE READING
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