Effect of anti-inflammatory bowel disease drug, E3040, on urate transport in rat renal brush border membrane vesicles.

@article{Yamada2000EffectOA,
  title={Effect of anti-inflammatory bowel disease drug, E3040, on urate transport in rat renal brush border membrane vesicles.},
  author={Hiroshi Y Yamada and Hajime Kotaki and Tsunetoshi Itoh and Yasufumi Sawada and Tatsuji Iga},
  journal={European journal of pharmacology},
  year={2000},
  volume={406 1},
  pages={45-8}
}
To confirm the assumption that 6-hydroxy-5, 7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole (E3040) acts on urate reabsorption by inhibiting urate-anion exchange at the luminal membrane of renal tubules, we investigated the inhibitory effect of E3040 and its two conjugated metabolites on hydroxyl ion (OH(-)) gradient-dependent urate uptake into brush border membrane vesicles from rat renal cortex and compared it with other uricosuric agents. The order of potency was AA193 (5-chloro-7… CONTINUE READING