Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: in vitro microdialysis.

@article{Young1993EffectOA,
  title={Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: in vitro microdialysis.},
  author={Richard S K Young and Matthew John During and David F. Donnelly and William J Aquila and Victor L Perry and Gabriel G. Haddad},
  journal={The American journal of physiology},
  year={1993},
  volume={264 4 Pt 2},
  pages={R716-9}
}
Using in vitro microdialysis, we tested the hypothesis that anoxia-induced release of excitatory amino acids is greater in adult rat brain than in turtle brain. Ten minutes of anoxia produced significant elevation of glutamate (from 0.39 +/- 0.03 to 0.90 +/- 0.18 microM dialysate, means +/- SE, P < 0.05), aspartate (from 0.28 +/- 0.12 to 1.20 +/- 0.49 microM, P < 0.05), glycine, and alanine in the rat brain slice. During reoxygenation, alanine and glycine returned toward baseline values… CONTINUE READING