Effect of annual intramuscular vitamin D on fracture risk in elderly men and women--a population-based, randomized, double-blind, placebo-controlled trial.

@article{Smith2007EffectOA,
  title={Effect of annual intramuscular vitamin D on fracture risk in elderly men and women--a population-based, randomized, double-blind, placebo-controlled trial.},
  author={Helen Y. Smith and Frazer Anderson and Helen Raphael and Peter I Maslin and Sarah E. Crozier and Cyrus Cooper},
  journal={Rheumatology},
  year={2007},
  volume={46 12},
  pages={1852-7}
}
OBJECTIVES Low trauma fractures in older people incur enormous physical, social and economic costs. Previous research indicates that an annual intramuscular injection of vitamin D may reduce fracture rates in this group. This strategy requires validation in a population setting. METHODS Randomized, double-blind, placebo-controlled trial of 300,000 IU intramuscular (i.m.) vitamin D2 (ergocalciferol) injection or matching placebo every autumn over 3 years. 9440 people (4354 men and 5086 women… CONTINUE READING