Effect of angiotensin II type 2 receptor deletion in hematopoietic cells on brain ischemia-reperfusion injury.

@article{Iwanami2011EffectOA,
  title={Effect of angiotensin II type 2 receptor deletion in hematopoietic cells on brain ischemia-reperfusion injury.},
  author={Jun Iwanami and Masaki Mogi and Kana Tsukuda and Li-juan Min and Akiko Sakata and Fei Jing and Kousei Ohshima and Masatsugu Horiuchi},
  journal={Hypertension},
  year={2011},
  volume={58 3},
  pages={404-9}
}
The angiotensin II type 2 (AT(2)) receptor is expressed in bone marrow cells and may affect cell differentiation. We previously reported a beneficial role of the AT(2) receptor in ischemic brain damage. Here, we investigated the effect of AT(2) receptor stimulation in hematopoietic cells on ischemic brain injury using chimeric mice. Chimeric mice were generated by bone marrow transplantation into wild-type mice after irradiation. Bone marrow cells were prepared from wild-type (Agtr2(+)) or AT(2… CONTINUE READING
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