Effect of androgens on plasma somatomedin-C/insulin-like growth factor I responses to growth hormone.


In search of the mechanism for the relatively high plasma somatomedin-C (Sm-C) concentrations in pubertal boys and girls, we have measured the plasma Sm-C responses to exogenous growth hormone (GH) in prepubertal hypopituitary boys before and after testosterone administration. Sm-C responses were determined in 5 hypopituitary boys (9-14 years of age) who… (More)