Effect of anastrozole and tamoxifen on lipid metabolism in Japanese postmenopausal women with early breast cancer.

@article{Sawada2005EffectOA,
  title={Effect of anastrozole and tamoxifen on lipid metabolism in Japanese postmenopausal women with early breast cancer.},
  author={Shojiro Sawada and Kazuhiko Sato and Masatoshi Kusuhara and Makoto Ayaori and Atsushi Yonemura and Kuniyoshi Tamaki and Hoshio Hiraide and Hidetaka Mochizuki and Fumitaka Ohsuzu},
  journal={Acta oncologica},
  year={2005},
  volume={44 2},
  pages={134-41}
}
Endocrine therapies that profoundly decrease estrogen levels potentially have a detrimental effect on the cardiovascular system. This study evaluated the effect on lipid metabolism of one such agent, the new generation aromatase inhibitor anastrozole, compared with tamoxifen, when used as adjuvant treatment in postmenopausal Japanese women with early breast cancer. All patients had completed primary surgery and were randomized to anastrozole 1 mg once daily (n=22) or tamoxifen 20 mg once daily… CONTINUE READING