Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes.

  title={Effect of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes.},
  author={Tatsuhiro Matsuo and Hiroyuki Odaka and Hiroki Ikeda},
  journal={The American journal of clinical nutrition},
  volume={55 1 Suppl},
A new disaccharidase inhibitor, AO-128, showed 190-3900-fold more potent inhibition of purified rat small intestine sucrase-isomaltase (S-1) complex and 23-33-fold more potent inhibition of semipurified porcine small intestine disaccharidases than acarbose. AO-128 suppressed elevation of the blood glucose concentration after oral sucrose, maltose, and starch, but not after oral glucose, fructose, and lactose. The chronic addition of AO-128 to the diet produced antiobesity and antidiabetic… CONTINUE READING


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