Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: the TIME2 randomized controlled trial.

@article{Davies2012EffectOA,
  title={Effect of an indwelling pleural catheter vs chest tube and talc pleurodesis for relieving dyspnea in patients with malignant pleural effusion: the TIME2 randomized controlled trial.},
  author={Helen E. Davies and Eleanor K. Mishra and Brennan C Kahan and John Matthew Wrightson and Andrew E Stanton and Anur Guhan and Christopher W. H. Davies and Jamal Grayez and Richard Harrison and Anjani Prasad and N Crosthwaite and Yonghyeok Lee and Robert J Davies and Robert F. Miller and Najib M Rahman},
  journal={JAMA},
  year={2012},
  volume={307 22},
  pages={
          2383-9
        }
}
CONTEXT Malignant pleural effusion causes disabling dyspnea in patients with a short life expectancy. Palliation is achieved by fluid drainage, but the most effective first-line method has not been determined. OBJECTIVE To determine whether indwelling pleural catheters (IPCs) are more effective than chest tube and talc slurry pleurodesis (talc) at relieving dyspnea. DESIGN Unblinded randomized controlled trial (Second Therapeutic Intervention in Malignant Effusion Trial [TIME2]) comparing… CONTINUE READING
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