Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death.

@article{Inokuchi2009EffectOA,
  title={Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death.},
  author={Yuta Inokuchi and Yoshimi Nakajima and Masamitsu Shimazawa and Takanori Kurita and Mikiko Kubo and Atsushi Saito and Hironao Sajiki and Takashi Kudo and Makoto Aihara and Kazunori Imaizumi and Makoto Araie and Hideaki Hara},
  journal={Investigative ophthalmology & visual science},
  year={2009},
  volume={50 1},
  pages={
          334-44
        }
}
PURPOSE The effect of a preferential inducer of 78 kDa glucose-regulated protein (GRP78)/immunoglobulin heavy-chain binding protein (BiP; BiP inducer X, BIX) against tunicamycin-induced cell death in RGC-5 (a rat ganglion cell line), and also against tunicamycin- or N-methyl-D-aspartate (NMDA)-induced retinal damage in mice was evaluated. METHODS In vitro, BiP mRNA was measured after BIX treatment using semi-quantitative RT-PCR or real-time PCR. The effect of BIX on tunicamycin (at 2 microg… CONTINUE READING

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