Effect of an immunotoxin to folate receptor beta on bleomycin-induced experimental pulmonary fibrosis.

@article{Nagai2010EffectOA,
  title={Effect of an immunotoxin to folate receptor beta on bleomycin-induced experimental pulmonary fibrosis.},
  author={Taku Nagai and Minoru Tanaka and Kazuhisa Hasui and Hiroshi Shirahama and Shinichi Kitajima and Suguru Yonezawa and Biao Xu and Takami Matsuyama},
  journal={Clinical and experimental immunology},
  year={2010},
  volume={161 2},
  pages={348-56}
}
It has been suggested that alveolar and interstitial macrophages play a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) by producing proinflammatory and/or fibrogenic cytokines. We showed that inflammatory macrophages expressed folate receptor beta (FRbeta) while resident macrophages in normal tissues expressed no or low levels of FRbeta. In the present study, we examined the distribution of FRbeta-expressing macrophages in the lungs of patients with usual idiopathic… CONTINUE READING
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