Effect of an arginine analogue on acetylcholine-induced coronary microvascular dilatation in dogs.

@article{Komaru1991EffectOA,
  title={Effect of an arginine analogue on acetylcholine-induced coronary microvascular dilatation in dogs.},
  author={Tatsuya Komaru and Kathryn G. Lamping and C L Eastham and David G Harrison and Melvin L. Marcus and Kevin C. Dellsperger},
  journal={The American journal of physiology},
  year={1991},
  volume={261 6 Pt 2},
  pages={H2001-7}
}
The purpose of this study was to elucidate the contribution of endothelium-derived relaxing factor (EDRF) derived from arginine to acetylcholine (ACh)-induced coronary arteriolar vasodilatation in vivo. Experiments were performed in 62 open-chest anesthetized dogs. Internal diameters of small arterioles (less than 120 microns) and large arterioles (greater than 120 microns) were measured using an intravital microscope and stroboscopic epiillumination synchronized to the cardiac cycle. Topically… CONTINUE READING
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