Effect of an antiserotoninergic drug, metergoline, on the ACTH and cortisol response to insulin hypoglycemia and lysine-vasopressin in man.

@article{Cavagnini1976EffectOA,
  title={Effect of an antiserotoninergic drug, metergoline, on the ACTH and cortisol response to insulin hypoglycemia and lysine-vasopressin in man.},
  author={Francesco Cavagnini and Umberto Raggi and Piero Micossi and Anna Di Landro and Cecilia Invitti},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1976},
  volume={43 2},
  pages={
          306-12
        }
}
The effect of metergoline, a specific antiserotoninergic drug, on ACTH secretion was investigated in 29 normal volunteers and in 4 patients with increased ACTH production (3 with Addison's disease, 1 with Cushing's disease). In 15 normal subjects, a 4-day treatment with 10 mg daily of metergoline significantly blunted the ACTH response to insulin hypoglycemia. Mean peak ACTH values before and after treatment were, respectively, 333 +/- 39.2 (SE) and 235 +/- 38.8 pg/ml (P less than 0.05). The… CONTINUE READING
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