Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis.

@article{Molteni2007EffectOA,
  title={Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis.},
  author={Agostino Molteni and Lisa F. Wolfe and William F. Ward and Chung H Ts'ao and Loredana Brizio Molteni and Patricia A. Veno and Brian L. Fish and Joan M. Taylor and Norma M Quintanilla and Betty L. Herndon and John E Moulder},
  journal={Current pharmaceutical design},
  year={2007},
  volume={13 13},
  pages={
          1307-16
        }
}
Progressive, irreversible fibrosis is one of the most clinically significant consequences of ionizing radiation on normal tissue. When applied to lungs, it leads to a complication described as idiopathic pneumonia syndrome (IPS) and eventually to organ fibrosis. For its high mortality, the condition precludes treatment with high doses of radiation. There is widespread interest to understand the pathogenetic mechanisms of IPS and to find drugs effective in the prevention of its development. This… CONTINUE READING

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