Effect of an angiotensin II receptor antagonist, TCV-116, on cardiac hypertrophy and coronary circulation in spontaneously hypertensive rats.

@article{Takeda1994EffectOA,
  title={Effect of an angiotensin II receptor antagonist, TCV-116, on cardiac hypertrophy and coronary circulation in spontaneously hypertensive rats.},
  author={Kazunori Takeda and Hiroyuki Fujita and Ko Nakamura and Akira Uchida and Masakazu Tanaka and Hiroshi Itoh and Tetsuo Nakata and Satoshi Sasaki and Masao Nakagawa},
  journal={Blood pressure. Supplement},
  year={1994},
  volume={5},
  pages={94-8}
}
To determine whether an angiotensin II receptor antagonist (AT antagonist) could improve the impaired coronary circulation as well as induce regression of cardiac hypertrophy in the hypertensive heart, and to elucidate whether the nitric oxide system in the coronary artery was involved in this mechanism, the AT1 antagonist, TCV-116 (10 mg/kg), was administered orally to spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY), and coronary flow was measured in the isolated hearts. High… CONTINUE READING

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