Effect of an activated charcoal product (DOAC Stop™) intended for extracting DOACs on various other APTT-prolonging anticoagulants

@article{Exner2019EffectOA,
  title={Effect of an activated charcoal product (DOAC Stop™) intended for extracting DOACs on various other APTT-prolonging anticoagulants},
  author={T. Exner and M. Ahuja and Lisa Ellwood},
  journal={Clinical Chemistry and Laboratory Medicine (CCLM)},
  year={2019},
  volume={57},
  pages={690 - 696}
}
  • T. Exner, M. Ahuja, Lisa Ellwood
  • Published 2019
  • Medicine
  • Clinical Chemistry and Laboratory Medicine (CCLM)
  • Abstract Background The aim of the study was to investigate the specificity of an activated charcoal-based product (DOAC Stop™) initially intended for the specific extraction of direct oral anticoagulants (DOACs) from test plasmas on a range of other anticoagulants. Methods Test plasmas were prepared by adding various anticoagulants to pooled normal plasma at concentrations prolonging an activated partial thromboplastin time (APTT) test by a factor of 1.5–3. These plasmas were treated with DOAC… CONTINUE READING
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    References

    SHOWING 1-10 OF 17 REFERENCES
    Simple method for removing DOACs from plasma samples.
    • 44
    The prolonged activated clotting time (ACT) with aprotinin depends on the type of activator used for measurement
    • 54
    Evaluation of the DOAC-Stop® Procedure to Overcome the Effect of DOACs on Several Thrombophilia Screening Tests
    • 32
    • PDF
    Antidotes for novel oral anticoagulants: current status and future potential.
    • 104
    Effect of Activated Charcoal on Apixaban Pharmacokinetics in Healthy Subjects
    • 115
    • PDF
    Effect of Activated Charcoal on Rivaroxaban Complex Absorption
    • 15
    The adsorption of dabigatran is as efficient as addition of idarucizumab to neutralize the drug in routine coagulation assays
    • 17
    The effects of protamine overdose on coagulation parameters as measured by the thrombelastograph
    • 49
    • PDF
    Inhibition of Hageman factor activation.
    • 76
    • PDF
    Diagnostic methodologies for circulating anticoagulants.
    • T. Exner
    • Medicine
    • Thrombosis and haemostasis
    • 1995
    • 35