Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs.

@article{Churg2007EffectOA,
  title={Effect of an MMP-9/MMP-12 inhibitor on smoke-induced emphysema and airway remodelling in guinea pigs.},
  author={Andrew Churg and Rona X Wang and Xiao Shaun Wang and P O Onnervik and Kerstin Thim and Joanne L. Wright},
  journal={Thorax},
  year={2007},
  volume={62 8},
  pages={706-13}
}
BACKGROUND Matrix metalloproteases (MMPs) are believed to be important in the pathogenesis of cigarette smoke-induced emphysema, but this hypothesis has only been proved in the mouse and its applicability to other species, particularly humans, is uncertain. The role of MMPs in smoke-induced small airway remodelling is unknown. METHODS The effects of a dual MMP-9/MMP-12 inhibitor, AZ11557272, on the development of anatomical and functional changes of chronic obstructive pulmonary disease (COPD… CONTINUE READING

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