Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease.

@article{Dennis2006EffectOA,
  title={Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease.},
  author={Carly G. Dennis and William R. Greco and Yseult Brun and Richard C Youn and Harry K. Slocum and Ralph J. Bernacki and Russell F Lewis and Nathan P Wiederhold and Steven M Holland and Ruta Petraitiene and Thomas J Walsh and Brahm H. Segal},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 2},
  pages={422-7}
}
Chronic granulomatous disease (CGD) is an inherited disorder of the NADPH oxidase characterized by recurrent life-threatening bacterial and fungal infections. We characterized the effects of single and combination antifungal therapy on survival, histopathology, and laboratory markers of fungal burden in experimental aspergillosis in the p47phox-/- knockout mouse model of CGD. CGD mice were highly susceptible to intratracheal Aspergillus fumigatus challenge, whereas wild-type mice were resistant… CONTINUE READING

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