Effect of aminoguanidine and cyclosporine on lung allograft rejection.

  title={Effect of aminoguanidine and cyclosporine on lung allograft rejection.},
  author={P Mattsson and Adrianna Zeevi and Jiming Cai and Samuel A. Yousem and Rebecca Hoffman and Michael Nalesnik and Gilbert J. Burckart and Daryl Geller and Bartley P. Griffith},
  journal={The Annals of thoracic surgery},
  volume={62 1},
BACKGROUND Aminoguanidine, a nitric oxide synthase inhibitor, has been shown to reduce the inflammatory allogeneic response. Here we used it in combination with cyclosporine to evaluate its effect on a clinically relevant immunosuppressive protocol. METHODS Orthotopic left lung transplantation was performed in 120 rats, of which 24 were syngeneic Lewis to Lewis controls, and allogeneic transplantations were performed across major histoincompatibility barriers (ACI to Lewis). We studied… CONTINUE READING