Effect of amino acid substitutions in the GerAA protein on the function of the alanine-responsive germinant receptor of Bacillus subtilis spores.

@article{Mongkolthanaruk2011EffectOA,
  title={Effect of amino acid substitutions in the GerAA protein on the function of the alanine-responsive germinant receptor of Bacillus subtilis spores.},
  author={Wiyada Mongkolthanaruk and Gareth R Cooper and Julia S. P. Mawer and Raymond N Allan and A C P Moir},
  journal={Journal of bacteriology},
  year={2011},
  volume={193 9},
  pages={2268-75}
}
Spores of Bacillus subtilis require the GerAA, GerAB, and GerAC receptor proteins for L-alanine-induced germination. Mutations in gerAA, both random and site directed, result in phenotypes that identify amino acid residues important for receptor function in broad terms. They highlight the functional importance of two regions in the central, integral membrane domain of GerAA. A P324S substitution in the first residue of a conserved PFPP motif results in a 10-fold increase in a spore's… CONTINUE READING
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