Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data.

@article{Bourhis2011EffectOA,
  title={Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data.},
  author={Jean Henri Bourhis and Pierre Blanchard and Emilie Maillard and David M. Brizel and Benjamin Movsas and Jens Buentzel and Johannes A. Langendijk and Ritsuko Komaki and Swan Swan Leong and Peter C. Levendag and Jean-Pierre Pignon},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2011},
  volume={29 18},
  pages={2590-7}
}
PURPOSE Controversy exists regarding whether or not amifostine might reduce the efficacy of cancer treatment. The aim of this meta-analysis was to evaluate the impact of amifostine on overall survival (OS) and progression-free survival (PFS) in patients treated with radiotherapy or chemoradiotherapy. MATERIAL AND METHODS Updated data from individual patients with non-small-cell lung cancer, head and neck squamous cell carcinoma, and pelvic cancer treated with radiotherapy or chemoradiotherapy… CONTINUE READING