Effect of ambroxol on pneumonia caused by Pseudomonas aeruginosa with biofilm formation in an endotracheal intubation rat model.

@article{Li2011EffectOA,
  title={Effect of ambroxol on pneumonia caused by Pseudomonas aeruginosa with biofilm formation in an endotracheal intubation rat model.},
  author={Fang Li and Wenlei Wang and Linyan Hu and Lu-quan Li and Jialin Yu},
  journal={Chemotherapy},
  year={2011},
  volume={57 2},
  pages={173-80}
}
BACKGROUND Pseudomonas aeruginosa, especially the mucoid phenotype, is responsible for most of the morbidity and mortality in ventilator-associated pneumonia. Although ambroxol is widely used in neonatal lung problems as a mucolytic as well as an antioxidant agent, its anti-infective role is not well demonstrated by studies in vivo. OBJECTIVE To explore the effect of ambroxol on the biofilms of mucoid P. aeruginosa and on the associated lung infection using a rat model. METHODS We developed… CONTINUE READING

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