Effect of alprazolam on digoxin kinetics and creatinine clearance.

  title={Effect of alprazolam on digoxin kinetics and creatinine clearance.},
  author={Hermann Rudolf Ochs and David J Greenblatt and B. Verburg-Ochs},
  journal={Clinical pharmacology and therapeutics},
  volume={38 5},
Eight healthy men received a single, 1.25 mg dose of digoxin on two occasions, once in an otherwise drug-free control state and again while concurrently receiving alprazolam, 1.5 mg/day. There was no significant difference between control and alprazolam conditions in digoxin volume of distribution (11.0 vs. 11.2 L/kg), elimination t1/2 (46 vs. 41 hours), or total clearance from serum (2.8 vs. 3.6 ml/min/kg). Alprazolam coadministration slightly reduced mean 96-hour urinary excretion of digoxin… CONTINUE READING