Effect of alpha-tocopherol on the binding of benzo(a)pyrene to nuclear macromolecules.

Abstract

The binding of metabolically activated 14C-benzo(a)pyrene (BP) to rat liver nuclei was studied. The nuclear framework structure, termed the nuclear matrix, was found to bind BP preferably. alpha-Tocopherol inhibited the binding of BP to nuclear macromolecules in the presence of phenobarbital (PB)-induced microsomes. alpha-Tocopherol decreased the level of BP metabolites in nuclei, though it did not inhibit the activation of BP by PB-induced microsomes.

Cite this paper

@article{Matsuura1979EffectOA, title={Effect of alpha-tocopherol on the binding of benzo(a)pyrene to nuclear macromolecules.}, author={Tomokazu Matsuura and Hidetsugu Ueyama and Shinhachiro Nomi and K. Ueda}, journal={Journal of nutritional science and vitaminology}, year={1979}, volume={25 6}, pages={495-504} }