• Corpus ID: 25690035

Effect of alpha-tocopherol on cytotoxicity induced by UV irradiation and antioxidants.

@article{Sakagami1997EffectOA,
  title={Effect of alpha-tocopherol on cytotoxicity induced by UV irradiation and antioxidants.},
  author={Hiroshi Sakagami and Kazue Satoh and Y Makino and Toshichika Kojima and M. Takeda},
  journal={Anticancer research},
  year={1997},
  volume={17 3C},
  pages={
          2079-82
        }
}
The addition of DL-alpha-tocopherol (vitamin E) at the time of UV irradiation only marginally protects cells from UV-induced cytotoxicity. However, a protective effect of alpha-tocopherol emerged when it was added to the cells before UV irradiation, alpha-Tocopherol was progressively and dose-dependently incorporated into the cells. Washout experiments showed that the intracellular concentration of alpha-tocopherol decreased with an approximate half-life of 14-20 hours, due to the release from… 
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