Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study.

@article{Morcos2001EffectOA,
  title={Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study.},
  author={M. Morcos and V. Borcea and Berend Isermann and S. Gehrke and T Ehret and Marcella D. Henkels and Stephan Schiekofer and Marion A. Hofmann and Jean Amiral and H. -J. Tritschler and Ralph Ziegler and Peter Wahl and Peter P Nawroth},
  journal={Diabetes research and clinical practice},
  year={2001},
  volume={52 3},
  pages={175-83}
}
Oxidative stress plays a central role in the pathogenesis and progression of late microangiopathic complications (diabetic nephropathy) in diabetes mellitus. Previous studies suggested that treatment of diabetic patients with the antioxidant alpha-lipoic acid reduce oxidative stress and urinary albumin excretion. In this prospective, open and non-randomized study, the effect of alpha-lipoic acid on the progression of endothelial cell damage and the course of diabetic nephropathy, as assessed by… CONTINUE READING
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