Effect of alpha lipoic acid on ifosfamide-induced central neurotoxicity in rats

@article{Ozturk2014EffectOA,
  title={Effect of alpha lipoic acid on ifosfamide-induced central neurotoxicity in rats},
  author={Gulfer Ozturk and Zeynep Giniş and Sefika Nur Kurt and A. Albayrak and Sule Bilen and Ersin Fadillioglu},
  journal={International Journal of Neuroscience},
  year={2014},
  volume={124},
  pages={110 - 116}
}
Ifosfamide (IFOS) which is a cytotoxic alkylating agent may cause central nervous system toxicity. Alpha-lipoic acid (ALA) has a strong antioxidant effects. We hypothesized that ALA could attenuate on ifosfamide-induced central neurotoxicity in rats. Rats were divided into Control, IFOS, ALA and IFOS+ALA groups. The toxic effects of IFOS were analyzed by oxidative parameters and caspase 3 immunohistochemical examinations of brain tissue. The catalase activity of IFOS group significantly reduced… 
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