Effect of alpha-amanitin on ribonucleic acid polymerase II of rat brain nuclei and on retention of avoidance conditioning.

@article{Montanaro1971EffectOA,
  title={Effect of alpha-amanitin on ribonucleic acid polymerase II of rat brain nuclei and on retention of avoidance conditioning.},
  author={Nicola Montanaro and Francesco Novello and Fiorenzo Stirpe},
  journal={The Biochemical journal},
  year={1971},
  volume={125 4},
  pages={1087-90}
}
1. alpha-Amanitin inhibits in vitro the activity of RNA polymerase II of rat brain nuclei. 2. The toxin does not pass the blood-brain barrier, but when injected intracerebrally is highly toxic for rats, and causes inhibition of RNA polymerase II of isolated brain nuclei. 3. Intracerebral injection of alpha-amanitin 6h before training to a passive avoidance task is followed by impaired performance of rats on retesting after 7 days, without affecting performance on retesting immediately after… CONTINUE READING

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Biochem

P. Chambon
biophys. Res. Commun. 38, 165. • 1970

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