Effect of alpha 1 adrenoceptor antagonists on prostatic pressure and blood pressure in the anesthetized dog.

@article{Kenny1994EffectOA,
  title={Effect of alpha 1 adrenoceptor antagonists on prostatic pressure and blood pressure in the anesthetized dog.},
  author={Bob Kenny and Alasdair M Naylor and Adrian J Carter and Andrew M. Read and P M Greengrass and Michael G. Wyllie},
  journal={Urology},
  year={1994},
  volume={44 1},
  pages={52-7}
}
OBJECTIVES In the current study we have profiled a range of compounds at alpha 1 adrenoceptor subtypes in vitro and have assessed their effects in vivo using the anesthetized dog in an attempt to elucidate the predominant alpha 1 adrenoceptor subtype mediating contractile responses of the canine prostate. METHODS The affinity of compounds for alpha 1 adrenoceptor subtypes was determined by displacement of [3H] prazosin binding from stably transfected rat 1 fibroblasts expressing alpha 1A… CONTINUE READING

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