Effect of almitrine on ventilation-perfusion distribution in adult respiratory distress syndrome.

@article{Reyes1988EffectOA,
  title={Effect of almitrine on ventilation-perfusion distribution in adult respiratory distress syndrome.},
  author={A I Reyes and Josep Roca and Roberto Rodr{\'i}guez-Rois{\'i}n and Antoni Torres and Piedad Ussetti and Peter D. Wagner},
  journal={The American review of respiratory disease},
  year={1988},
  volume={137 5},
  pages={1062-7}
}
Almitrine improves ventilation/perfusion relationships (VA/Q) in COPD, but its effects in ARDS, in which VA/Q mismatching is the cause of severe hypoxemia, are not known. The effects of almitrine on pulmonary gas exchange and circulation were assessed in 9 patients with ARDS who were sedated, paralyzed, and mechanically ventilated at constant FlO2 (range, 0.48 to 0.74). Systemic and pulmonary hemodynamics, conventional gas exchange, and the VA/Q distribution by the multiple inert gas… CONTINUE READING
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