Effect of allopurinol on the hepatic and cerebellar iron, selenium, zinc and copper status following acute ethanol administration to rats.

@article{Houz1991EffectOA,
  title={Effect of allopurinol on the hepatic and cerebellar iron, selenium, zinc and copper status following acute ethanol administration to rats.},
  author={Pascal Houz{\'e} and H{\'e}l{\`e}ne Rouach and Maximilien Gentil and Marie Th{\'e}r{\`e}se Orfanelli and Roger Nordmann},
  journal={Free radical research communications},
  year={1991},
  volume={12-13 Pt 2},
  pages={
          663-8
        }
}
An acute ethanol load (50 mmol/kg, i.p.) induces an increase in the total non-heme iron and in the low-molecular-weight non-heme iron complexes (LMW-Fe) content both in liver and cerebellum. This increase in LMW-Fe is associated with a decrease in some essential trace elements (selenium, zinc, copper) playing a role in the anti-oxidant system. These changes could contribute to the enhancement in lipid peroxidation which occurs at the hepatic and cerebellar level following the ethanol… CONTINUE READING