Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency.

@article{Bickford2013EffectOA,
  title={Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency.},
  author={Justin S. Bickford and C. Mueller and Kimberly J. Newsom and Sarah J. Barilovits and Dawn E. Beachy and J. D. Herlihy and B. Keeler and T. Flotte and H. Nick},
  journal={Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society},
  year={2013},
  volume={12 3},
  pages={
          258-65
        }
}
  • Justin S. Bickford, C. Mueller, +6 authors H. Nick
  • Published 2013
  • Medicine
  • Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
  • BACKGROUND Allergic bronchopulmonary aspergillosis (ABPA) is a complicating factor in cystic fibrosis (CF), affecting 2-15% of patients. We hypothesized that sensitization/challenge of CFTR(-/-) mice with an Aspergillus fumigatus (Af) extract will affect eicosanoid pathway gene expression, impacting ABPA and CF. METHODS FABP-hCFTR(+/-)-CFTR(-/-) mice were sensitized/challenged with an Af extract and gene expression of lung mRNA was evaluated for >40 genes, with correlative data in human CF… CONTINUE READING
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    References

    SHOWING 1-10 OF 42 REFERENCES
    Enhanced IgE allergic response to Aspergillus fumigatus in CFTR−/− mice
    • 29
    • PDF
    Eicosanoids: mediators and therapeutic targets in fibrotic lung disease.
    • 69
    • PDF
    Mice lacking 12/15-lipoxygenase have attenuated airway allergic inflammation and remodeling.
    • 67
    Cystic fibrosis transmembrane conductance regulator regulates epithelial cell response to Aspergillus and resultant pulmonary inflammation.
    • 57
    Aspergillus and asthma--any link?
    • 58
    • PDF
    Factors effecting impact of Aspergillus fumigatus sensitization in cystic fibrosis
    • 28
    Calcium-dependent regulation of NF-κB activation in cystic fibrosis airway epithelial cells
    • 65
    Interleukin-4 Induces 15-Lipoxygenase-1 Expression in Human Orbital Fibroblasts from Patients with Graves Disease
    • 45
    • PDF