Corpus ID: 30038700

Effect of alkalosis on ouabain toxicity in the dog.

@article{Galmarini1973EffectOA,
  title={Effect of alkalosis on ouabain toxicity in the dog.},
  author={Dinangelo Galmarini and Juan Francisco Campodonico and R. Wenk},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1973},
  volume={186 1},
  pages={
          199-203
        }
}
The effect of acute alkalosis induced by either hyperventilation or sodium carbonate on the toxicity of ouabain and the importance of secondary alterations in blood pCO2 and plasma concentrations of sodium, calcium and potassium on this toxicity was studied in dogs. The mean lethal dose of ouabain in groups of dogs which had been 1) hyperventilated, 2) given sodium carbonate by infusion, 3) hyperventilated and given supplemental potassium by infusion and 4) given sodium carbonate plus… Expand
Glycoside Inotropy in the Absence of an Increase in Potassium Efflux in the Rabbit Heart
TLDR
It is demonstrated that during acidosis ACS inhibits sodium-potassium adenosinetriphosphatase (Na+-K+ ATPase) and causes an inotropic effect but does not increase K+ efflux, which gives further support to the proposal that digitalis-induced inotropy is secondary to an enhancement of a Na+-Ca2+ exchange system. Expand
Evaluation of Cardiac Glycosides in the Intact Animal
TLDR
Experimental animals have been employed mainly to determine the therapeutic range, intestinal absorption, and duration of action of new glycosides or semisynthetic derivatives and interactions with other drugs which potentiate or attentuate their effects or which alter their therapeutic range. Expand
Digitalis Toxicity
  • J. Bigger
  • Medicine
  • Journal of clinical pharmacology
  • 1985
The principal causes of digitalis toxicity are overdose, reduced volume of distribution, reduced renal elimination, and increased myocardial sensitivity. The metabolic mechanism of digitalis toxicityExpand
Interactions Between Cardiac Glycosides and Other Substances in the Body
It is well documented that cardiac glycosides require careful dosage adjustment in the individual patient to achieve satisfactory clinical responses without toxic symptoms. Many factors contribute toExpand
Pulmonary Disease and Drug Kinetics
TLDR
It is apparent that respiratory disease significantly changes drug disposition through a number of interacting mechanisms, and general principles are emerging: Drugs showing flow-dependent hepatic clearance and those drugs showing predominant renal clearance should be used with caution. Expand
Factors affecting tolerance to digitalis.
  • B. Surawicz
  • Medicine
  • Journal of the American College of Cardiology
  • 1985
TLDR
The most important factors contributing to decreased tolerance and risk of toxicity are: heart disease, poor renal function, hypokalemia and hypothyroidism. Expand
Digitalis toxicity: epidemiology and clinical use of serum concentration measurements.
  • T. Smith
  • Medicine
  • The American journal of medicine
  • 1975
TLDR
Results of studies to date demonstrate that mean serum digoxin and digitoxin levels are significantly higher in patients with electrocardiographic evidence of toxicity compared with patients without such evidence, suggesting sole dependence on these levels for established of a diagnosis of digitalis toxicity is not warranted. Expand
The use of digitalis in patients with pulmonary disease.
TLDR
Indications for digitalis therapy with particular emphasis on its role in the management of cor pulmonale, the evidence for an enhanced sensitivity to cardiac glycosides, and the possible mechanisms underlying such sensitivity in patients with pulmonary disease are considered. Expand
Critical care cardiology.
  • P. Fox
  • Medicine
  • The Veterinary clinics of North America. Small animal practice
  • 1989
TLDR
A wide range of cardiovascular drugs is available for treatment of shock, congestive heart failure, and arrhythmias. Expand
Interaktionen von Anästhetika und anderen Pharmaka
Eine sinnvolle pharmakologische Therapie ist einerseits in vielen Fallen nur durch das Zusammenspiel von 2 oder mehreren Medikamenten uberhaupt erst muglich, andererseits kunnen WechselwirkungenExpand
...
1
2
...