Corpus ID: 30038700

Effect of alkalosis on ouabain toxicity in the dog.

  title={Effect of alkalosis on ouabain toxicity in the dog.},
  author={Dinangelo Galmarini and Juan Francisco Campodonico and R. Wenk},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={186 1},
The effect of acute alkalosis induced by either hyperventilation or sodium carbonate on the toxicity of ouabain and the importance of secondary alterations in blood pCO2 and plasma concentrations of sodium, calcium and potassium on this toxicity was studied in dogs. The mean lethal dose of ouabain in groups of dogs which had been 1) hyperventilated, 2) given sodium carbonate by infusion, 3) hyperventilated and given supplemental potassium by infusion and 4) given sodium carbonate plus… Expand
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