Effect of alkalinization of lidocaine on median nerve block.

@article{Ririe2000EffectOA,
  title={Effect of alkalinization of lidocaine on median nerve block.},
  author={Douglas Gordon Ririe and Francis O. Walker and Robert L. James and John E. Butterworth},
  journal={British journal of anaesthesia},
  year={2000},
  volume={84 2},
  pages={
          163-8
        }
}
Median nerve blocks were performed in 10 volunteers in a randomized, double-blind, crossover study to compare the effects of 1% plain lidocaine with 1% lidocaine in sodium bicarbonate 0.1 mmol litre-1. Sensations of hot, cold, pinprick and light touch, compound motor and sensory nerve action potentials, and skin temperature were assessed at 2-min intervals. pH was 6.4 +/- 0.1 for plain lidocaine and 7.7 +/- 0.2 for alkalinized lidocaine (P < 0.001). Alkalinized lidocaine produced more rapid… CONTINUE READING

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